Leo A B Joosten Selected Research

Toll-Like Receptor 2

9/2011	Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2.
11/2010	Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.
6/2010	Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction.
12/2008	Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.
12/2004	Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
12/2003	Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.

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Leo A B Joosten Research Topics

Disease

114	Inflammation (Inflammations) 05/2022 - 05/2002
59	Infections 03/2022 - 01/2009
38	Arthritis (Polyarthritis) 01/2021 - 05/2002
29	Rheumatoid Arthritis 01/2022 - 02/2003
18	Atherosclerosis 01/2022 - 08/2014
16	Gout 01/2022 - 07/2012
15	Lyme Disease (Disease, Lyme) 04/2022 - 06/2010
15	Experimental Arthritis 05/2013 - 11/2002
14	Obesity 10/2020 - 06/2006
13	Neoplasms (Cancer) 05/2022 - 08/2011
12	Tuberculosis (Tuberculoses) 11/2021 - 08/2006
12	Q Fever (Fever, Q) 01/2019 - 06/2013
12	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2016 - 03/2010
11	Sepsis (Septicemia) 03/2022 - 09/2009
11	Mycoses (Diseases, Fungus) 05/2021 - 10/2009
11	Insulin Resistance 01/2017 - 06/2006
9	COVID-19 01/2022 - 01/2020
8	Crohn Disease (Crohn's Disease) 03/2022 - 04/2008
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 11/2014
8	Candidiasis (Moniliasis) 01/2021 - 08/2010
7	Communicable Diseases (Infectious Diseases) 10/2021 - 08/2014
7	Leishmaniasis 01/2021 - 05/2014
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 07/2011
7	Fatigue 04/2019 - 10/2015
6	Melanoma (Melanoma, Malignant) 01/2021 - 01/2015
6	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 02/2006
6	Chronic Granulomatous Disease 03/2014 - 02/2010
5	Bacterial Infections (Bacterial Infection) 03/2022 - 01/2011
5	Non-alcoholic Fatty Liver Disease 10/2020 - 01/2016
5	Gouty Arthritis 01/2020 - 11/2010
5	Candidemia 01/2019 - 10/2011
4	Virus Diseases (Viral Diseases) 03/2022 - 07/2012
4	Rheumatic Diseases (Rheumatism) 01/2022 - 07/2013
4	Endotoxemia 01/2021 - 06/2009
4	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 11/2020 - 10/2015
4	Post-Lyme Disease Syndrome 04/2019 - 01/2011
4	Respiratory Tract Infections (Respiratory Tract Infection) 01/2019 - 12/2012
4	Necrosis 01/2018 - 04/2008
4	Systemic candidiasis 09/2017 - 01/2013
4	Invasive Fungal Infections 03/2014 - 10/2009

Drug/Important Bio-Agent (IBA)

121	CytokinesIBA 05/2022 - 05/2002
31	InflammasomesIBA 05/2022 - 09/2009
29	Interleukin-1 (Interleukin 1)IBA 01/2022 - 06/2003
24	InterleukinsIBA 05/2021 - 08/2006
24	Interleukin-17 (Interleukin 17)IBA 01/2021 - 03/2003
22	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2020 - 12/2003
20	Interleukin-6 (Interleukin 6)IBA 01/2021 - 06/2003
20	Pattern Recognition ReceptorsIBA 10/2020 - 04/2009
18	Proteins (Proteins, Gene)FDA Link 03/2022 - 09/2003
18	LigandsIBA 12/2020 - 03/2003
18	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2018 - 02/2003
17	Interleukin-18 (Interleukin 18)IBA 03/2021 - 02/2003
17	Uric Acid (Urate)IBA 01/2021 - 11/2010
11	VaccinesIBA 01/2021 - 12/2013
11	AntigensIBA 01/2021 - 09/2003
10	Biomarkers (Surrogate Marker)IBA 03/2022 - 12/2012
10	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 03/2021 - 02/2008
9	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2020 - 10/2003
9	dectin 1IBA 12/2015 - 10/2009
8	NucleotidesIBA 05/2022 - 04/2008
8	InterferonsIBA 01/2022 - 11/2011
8	Interleukin-10 (Interleukin 10)IBA 01/2021 - 02/2012
7	oxidized low density lipoproteinIBA 01/2022 - 01/2009
7	Interleukin-8 (Interleukin 8)IBA 10/2020 - 01/2012
7	Serine Proteases (Serine Protease)IBA 06/2020 - 12/2009
7	Messenger RNA (mRNA)IBA 01/2020 - 09/2003
7	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 09/2015 - 09/2007
6	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 09/2014
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 06/2009
6	Caspase 1 (ICE Protease)IBA 01/2016 - 12/2009
6	Toll-Like Receptor 2IBA 09/2011 - 12/2003
5	LipopolysaccharidesIBA 11/2021 - 04/2008
5	ZymosanIBA 11/2021 - 10/2003
5	C-Reactive ProteinIBA 01/2021 - 07/2011
5	ChemokinesIBA 01/2021 - 10/2003
5	NLR ProteinsIBA 01/2021 - 12/2008
5	dapansutrileIBA 01/2021 - 01/2018
5	Matrix Metalloproteinases (MMPs)IBA 11/2019 - 10/2003
5	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 02/2010
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 11/2010
5	C-Type Lectins (C-Type Lectin)IBA 09/2017 - 03/2010
5	Interleukin-1beta (Interleukin 1 beta)IBA 09/2014 - 02/2003
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2009
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2019
4	Histones (Histone)IBA 01/2021 - 04/2015
4	Carrier Proteins (Binding Protein)IBA 01/2021 - 06/2006
4	AntibodiesIBA 01/2021 - 09/2003
4	Tuberculosis VaccinesIBA 11/2020 - 12/2016
4	LipidsIBA 10/2020 - 01/2018
4	Protein Isoforms (Isoforms)IBA 01/2020 - 02/2016
4	CholesterolIBA 01/2020 - 11/2013
4	AldosteroneIBA 01/2020 - 01/2018
4	EnzymesIBA 01/2020 - 06/2003
4	GlucansIBA 09/2019 - 01/2011
4	Biological ProductsIBA 05/2019 - 07/2017
4	Proteoglycans (Proteoglycan)IBA 11/2009 - 06/2003

Therapy/Procedure

28	Therapeutics 05/2022 - 12/2003
5	Aftercare (After-Treatment) 04/2022 - 09/2007
4	Immunotherapy 05/2022 - 12/2010
4	Intra-Articular Injections 06/2012 - 10/2003